Much of weight gain on medications is subject to genetics. Take two people with identically healthy lifestyles and put them on the same dosage of Gabapentin for the same duration. One of those individuals may end up gaining 10 lbs., while the other may lose 5 lbs. What would explain the difference between these two individuals? Genetics as well as epigenetics or gene expression in response to the environment.

The use of parenteral phenytoin is complicated by poor solubility, high alkalinity, hypotension, cardiac arrhythmias and the potential for soft tissue injury with extravasation. However, fosphenytoin can be administered intravenously or intramuscularly with a low risk of tissue irritation. No significant electrocardiographic changes have been noted with either intravenous or intramuscular administration. Mild decrements in mean systolic blood pressure have been reported with intravenous administration.

Because false positive readings were reported with the Ames N-Multistix SG® dipstick test for urinary protein when gabapentin was added to other antiepileptic drugs, the more specific sulfosalicylic acid precipitation procedure is recommended to determine the presence of urine protein. Pain from damaged nerves (postherpetic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.

provides this medical information service in accordance with these terms and conditions Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. This drug was first formulated and synthesized in the year 1972, by researchers at Lundbeck, a Danish international pharmaceutical company. In certain cases, there may be worsening of symptoms seen, like increased frequency of mood swings, going into extreme depression, suicidal tendencies, etc,.

I started taking gabapentin 600 mg a few weeks ago at 900mg a day and the drug alleviated symptoms of my depression, anxiety, irritability, and I was able to sleep well again. The side effects of the medication even subsided over time. I notice now that some of my symptoms are coming creeping back to the point where my daily dosage of gabapentin will have to be increased gradually. Does this drug lose its effectiveness over time such that its dosage needs to be adjusted regularly? Thank you.